Huntington's disease: Hot on the trail of misfolded proteins' toxic modus operandi

Proteins are the workhorses of the cell, and their correctly folded three-dimensional structures are critical to cellular functions. Misfolded structures often fail to properly perform these vital jobs, leading to cellular stress and devastating neurodegenerative disorders such as Huntington's disease. Researchers are now gaining a better understanding of the relationship between protein misfolding, aggregation and cell toxicity.